Medscape1 个月
Instigation of Notch Signaling in the Pathogenesis of Kaposi's Sarcoma-associated ...
Lytic replication contributes to KSHV pathogenesis. Notch is a conserved signaling pathway with pleiotropic effects and strong involvement in development and cell fate determination. Deregulation ...
Medscape1 个月
Instigation of Notch Signaling in the Pathogenesis of Kaposi's Sarcoma-associated ...
HBV and HCV are the two major etiological agents of hepatocellular carcinomas. Aberrant activation of the Notch signaling pathway is found in cells derived from hepatocellular carcinomas ...
搜狐1 个月
临床洞见：小细胞肺癌的流行病学特征与分子分型变迁
尽管大多数SCLC表现出神经内分泌肿瘤的特征，但也存在一部分分型缺乏这些特性。通过对SCLC的基因组学分析发现，几乎所有患者都出现了抑癌基因TP53和RB1的失活，同时伴有高突变负荷。近年来，随着分子分型研究的进一步深入，SCLC的亚型也被重新定义 ...