The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, ...
Although, preclinical data suggest that the behavioral expression of opioid use is similar between male and female rodents, we do not have conclusive results on sex differences on craving and relapse ...
The structure of the EphA4 receptor SAM domain reveals a novel mechanism through which modular domains control protein–protein interactions. Since SAM domains are found in cell surface receptors ...
Sigma 1 receptor (S1R) is a multifunctional, ligand-activated protein located in the membranes ... Nonetheless, relatively little is known about the specific molecular mechanisms underlying S1R ...
A group of trade unions, health-care advocates and non-profits is calling on the province to take action against the opioid crisis, and they say construction workers continue to be especially ...
The regular use of agonists of the μ-opioid receptor for acute pain relief usually leads to tolerance, respiratory depression, constipation and importantly, abuse potential. Discontinuation of chronic ...