Current research has shown that the administration of opioids ... very different mechanisms. An allosteric model suggests that the binding of a ligand to a population of delta receptors results ...

Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to ...

The kappa opioid receptor was cloned in 1993 (Meng et al., 1993), while its pharmacological identification spans more than two-decades before. Portoghese and others proposed more than a single opioid ...

Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting ...

You will be redirected to our submission process. The kappa opioid receptor (KOR) and its endogenous ligands, the dynorphins, are expressed both in the central and peripheral nervous systems. The ...

The precise mechanism of action is not known but the effects are thought to be mediated through opioid-specific receptors located in the CNS. Use lowest effective dose for shortest duration.

Codeine sulfate is an opioid agonist relatively selective ... although the exact mechanism of analgesic action remains unknown. Serious and life-threatening risks from use of Codeine Sulfate ...

2006;40(11):2178-2186. The mechanism of action of fentanyl is best described by its agonist interaction with the opioid µ-receptor. These sites of interaction are primarily distributed throughout ...