The initial deposition of hydroxyapatite in the ECM (extracellular matrix) is mediated by extracellular vesicles. Calcification of the ECM induces osteogenic differentiation of healthy vascular smooth ...

This result is underpinned by the fact that mice in which this cGMP pathway was blocked, developed more severe vascular calcification. “Interestingly, precisely this pathway of cGMP formation ...

From the Hospital Israelita Albert Einstein, São Paulo, SP, Brazil (L.A.P., L.F.G., M.L.) Laboratório de Biologia Vascular, Instituto do Coração (InCor), Hospital ...

Differential expression of osteocalcin gene in relation to diabetes mellitus Cluster 2 is characterised by the core terms ‘expression’, ‘differential’, ‘diabetes’ and ‘osteoblasts’. In this group, ...

Vascular calcification (VC) is associated with a number of cardiovascular diseases, as well as chronic kidney disease. The role of smooth muscle cells (SMC) has already been widely explored in VC, as ...