CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple ...

Furthermore, liver-specific Ube2f knockout attenuates steatosis and tumorigenesis induced by Pten loss in an mTORC1-dependent manner, suggesting a causal role of UBE2F in liver tumorigenesis. Finally, ...

Overall this paper may offer insight into mechanisms by which BRCA1 deficiency fuels breast tumorigenesis. BRCA1 is a critical tumor suppressor, mutations in which greatly increase risks for many ...

The LCMS study revealed that PFBL is composed of approximately fifteen distinct compounds. PFBL promoted apoptotic cell death in both androgen-dependent LNCaP cells androgen-refractory PC3 and DU145 ...

The word is formed by "onco" (the Latin word for "tumor") and "genesis" meaning "beginning." “Tumorigenesis” is another term used for this process. Another word, “carcinogenesis,” means roughly the ...