In one study, the drug reduced blood levels of free PCSK9 protein by more than 90% from baseline when administered to healthy men as a single dose of between 10 and 300 mg, regardless of the dose ...

Obesity significantly impacts cardiovascular health, increasing risks such as left ventricular hypertrophy, atherosclerosis, ...

Verve Therapeutics has started dosing patients in a phase 1b trial of its in vivo gene-editing drug for high cholesterol, designed to permanently switch off the PCSK9 gene with a one-shot treatment.

Both types are effective at managing cholesterol, but researchers have uncovered some surprising side effects. Weight Gain: ...

Akeso, Inc. (9926.HK) ('Akeso' or the 'Company') is pleased to announce that the New Drug Application (NDA) of its internally-developed IL-17-targeting monoclonal antibody gumokimab (AK111) has been ...

ABSTRACT: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proprotein convertase (PCs) family, which facilitates the degradation of low-density lipoprotein receptors (LDL-R) ...

In conclusion, the current updated evidence suggested that PCSK9-mAb, a novel powerful lipid-lowering drug, had no significant impact on circulating hs-CRP concentrations, whose effect did not ...

PCSK9, which mediates post-translational destruction of LDL receptors, is raised in HoFH and is further raised by statins. LDL-C, following apheresis, quickly rebounds due to increased synthesis ...

Criticism over how the Chinese government buys drugs for its public health care system has ignited frustration over the quality of medicine. By Alexandra Stevenson and Zixu Wang Reporting from ...

We recently compiled a list of the 12 Best Blue Chip Stocks to Buy Under $100. In this article, we are going to take a look ...

Discover the potential of macrocycles in drug discovery: flexible, cell-permeable molecules targeting undruggable proteins.

NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS), a biopharmaceutical company with a market capitalization of $2.3 billion ...