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AstraZeneca meanwhile is also working on an oral PCSK9 inhibitor that it acquired from Dogma Therapeutics last year and is in early clinical development.

AstraZeneca has bought rights to an orally-active drug that inhibits PCSK9, offering a patient ... the first-in-class ATP citrate lyase (ACL) inhibitor could achieve peak sales in the region ...

Statins work by slowing down how much cholesterol your body produces. Another type, PCSK9 inhibitors, is newer and works differently. Instead of reducing cholesterol production, these drugs help ...

HDL is reduced. PCSK9, which reduces LDL receptor recycling, is increased. E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function, but its role in familial ...

Researchers have found that the mutations driving it may stem from a commonly inherited variant of the PCSK9 ... Nov. 22, 2024 — Researchers have discovered how the interplay between a key ...

Am J Health Syst Pharm. 2005;62(23):2481-2490.