Fibrosis is a leading cause of morbidity and mortality ... include transforming growth factor (TGF)- , connective tissue growth factor (CTGF), platelet-derived growth factor (PDGF), Interleukins, et ...

Immunohistochemistry studies also showed increased levels of CTGF and TGF-β1 ... a correlation between actual fibrosis and these markers. Many newly described signaling pathway proteins may ...

Principal investigators Matthias C. Kugler, MD, and John S. Munger, MD, are interested in signaling pathways relevant to lung development and fibrosis. Dr. Munger and collaborators showed that the ...

cells/field), and was also enhanced when cells were stimulated by PDGF (controls v IPF: 829 (222) v 1928 (600) cells/field). Fibroblasts from tissues with dense fibrosis had a greater capacity for ...

CTGF and col 1a1. Pomalidomide was also effective in the setting of pre-established fibrosis and reduced dermal thickness, myofibroblast counts and hydroxyproline content below pretreatment levels.

Several signaling molecules and transcription factors ... In addition, PPAR-d agonists prevent hepatic fibrosis in experimental rodent models. Many fibrogenic agonists such as PDGF, leptin, and ...

Proliferating HSCs further respond to stimuli derived from scar-associated macrophages and produce collagens and extracellular matrix, thereby promoting liver fibrosis. aHSCs, activated HSCs; PDGF ...

Smad3 and CTGF was aimed to demonstrate the expression of Smad- CTGF signalling pathway. Results Significant myocardial fibrosis characterised by Mason staining, Sirius red staining, up-regulation of ...

Similar to primary HSCs, both lines express key receptors regulating hepatic fibrosis, including platelet derived growth factor receptor β (βPDGF-R), obese receptor long form (Ob-R L), and discoidin ...

1 Liver Research Laboratory, University of Crete School of Medicine, Heraklion, Greece 2 Laboratory of Experimental Endocrinology, University of Crete School of Medicine, Heraklion, Greece ...