One significant area of research focuses on the PDGF/PDGFR signaling pathway and its implications in cancer. Studies have shown that many cancers express PDGFs and their receptors, which can ...

[78] Several potent non-selective tyrosine kinase inhibitors that interrupt both VEGF and PDGF signaling have been approved for cancer therapy: imatinib, sorafenib, pazopanib, sunitinib ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

A reduced number of master signalling pathways operate during development, acting repeatedly at different moments and regions in the embryo and eliciting diverse cellular responses. This raises the ...

Liver fibrosis and its end stage, liver cirrhosis, is the final common pathway of chronic liver diseases ... transforming growth factor (TGF)- , connective tissue growth factor (CTGF), ...

Two different signaling pathways Wnt and Shh both act on the PPAR-g gene to induce epigenetic repression ... In addition, PPAR-d agonists prevent hepatic fibrosis in experimental rodent models. Many ...

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Methods The production of a1-procollagen (a1-PROC) by rat HSCs treated with TNFα (100 ng/ml), TGFβ1 (5 ng/ml) or PDGF (32 ng/ml) and their cellular proliferation with or without octreotide was ...

Recent discoveries in ophthalmology and vascular biology, however, suggest that combined inhibition of VEGF and platelet-derived growth factor (PDGF) may be more beneficial than inhibition of VEGF ...

Three very important feasts and the pattern of the Tabernacle and the Ark of the Covenant — all symbolic of Christ and His relationship with believers today. And let them make Me a Sanctuary; that I ...

This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the ...