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Firstly, further elucidation of the molecular mechanisms of glycolysis and their differences in various stages and subtypes of GBM will aid in the development of more precise diagnostic tools and ...

However, when the researchers blocked an earlier step in glycolysis, the enzyme glucose-6-phosphate isomerase, this had no effect on the growth of the cancer cells. "The glycolytic enzyme aldolase ...

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Enzymes catalyze nearly all of the chemical reactions that occur in biological systems. Enzymes are generally proteins but also include catalytic DNA and catalytic RNA. As effective biological ...

1. HIF-1, as a transcription factor, enhances lactate production by regulating the expression levels of several key enzymes in glycolysis (HK, PGK, PFK, LDH, PDH and PKM2) and the glucose transport ...

The team evaluated more than 4,000 clones before identifying an enzyme S N Ar1.3 that contains six mutations and is 160-fold more active than the parent enzyme.

Scientists at the German Cancer Research Center (DKFZ) have now shown that liver cancer cells in mice and humans depend on a key enzyme of glycolysis, Aldolase A. When it is switched off ...

Even when glycolysis is blocked, they survive by obtaining their energy through the respiratory chain. This makes the results published by Almut Schulze and colleagues from the German Cancer Research ...

In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K. Protein kinase R-like ...