Myeloid FSTL1 deficiency suppresses M1 polarisation, reduces proinflammatory mediator expression and macrophage/neutrophil recruitment and alleviates liver fibrosis. FSTL1 directly binds to pyruvate ...

Macrophages exist in most tissues of the body, where they perform various functions at the same time equilibrating with other cells to maintain immune responses in numerous diseases including cancer.

In order to produce the necessary biological effects, macrophages (M0) can be polarized into pro-inflammatory (M1) and anti-inflammatory (M2) types in response to various microenvironmental stimuli.

Conclusion c-MET/ERK/p21/PKM2 cascade and VEGFR2-induced angiogenesis are the primary targets of cabozantinib ... However, it has limited impact on CAFs, macrophages and tumour infiltrating T cells.

A study in Nature Medicine developed a new clinical test based on a gut metagenome-derived multispecies biomarker panel for the diagnosis of inflammatory bowel disease, which outperformed faecal ...