肽核酸 (PNA) 是一种模拟 DNA 或 RNA 的人工合成聚合物。PNA 寡核苷酸可以与肽结合以提供额外的功能。肽-PNA 结合物 (KFFKFFKFFK-{CTCATACTCT}-NH2) 就是一个例子。它代表了对抗多重耐药细菌的尖端方法。此外CPP与PNA的结合也在生物医学领域具有良好前景。 2024年12月恒州诚 ...

Much of our work relies on peptide nucleic acid (PNA. Figure 1), a DNA mimic invented at the University of Copenhagen in 1991 by Nielsen, Egholm, Berg and Buchardt. In the first two projects described ...

We have also studied an alternative to DNA, the Peptide Nucleic Acids (PNA) which have a neutral backbone. An array of PNA probes complementary to tRNAphe was used to study the hybridisation ...

Objectives Our previous studies have successfully applied the radiometal-labeled DOTA-anti-bcl-2-PNA (peptide nucleic acid)-Tyr3-octreotate antisense conjugate for specific targeting of Mec-1 human ...

The Bell lab is currently developing nucleic acid ligands composed of DNA and peptide nucleic acids (PNA). PNA are used to enhance the in vivo stability of the resultant ligands. Professor Bell enjoys ...