Furthermore, Upadacitinib treatment, alone or in combination with IL-6, induces a modulation of acute and chronic pain-related genes. Conclusion: Our results show that Upadacitinib is crucial in ...

The immune system has long been recognised important in pain regulation through inflammatory cytokine modulation of peripheral nociceptive fibres. Recently, cytokine interactions in brain and spinal ...

Neurophysiological Biomarkers: Investigations into electrical, chemical, and neurophysiological signals that serve as biomarkers for treatment responsiveness and pain modulation. Exploration of EEG, ...

Research Interests: Pain modulation systems; immune and glial regulation of neuronal function; immune-to-brain communication; glial regulation of pain, opioid analgesia, drugs of abuse, ...

Applying neuromodulation protocols developed based on experimental unilateral modulation of M1 excitability to pain management is a rational starting point, but arguably is not optimized to broad pain ...

The ability to perceive pain from cutaneous to deeper tissues and organs is part of the normal sensory repertoire of many animal species. Nonetheless, ongoing chronic pain substantially reduces the ...

We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal ...