Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the ...

Pereira and colleagues suggest that Wnt5a is a highly specific autocrine and paracrine macrophage-derived effector ... by pathogens which leads to activation of noncanonical signaling in macrophages.

Liver fibrosis and its end stage, liver cirrhosis, is the final common pathway of chronic liver diseases ... The initiation phase of HSC activation is due to paracrine stimuli from injured neighboring ...

This important study reveals a critical role of the transcription factor NR2F2 in mouse fetal Leydig cell (FLC) differentiation. With elegantly carried out experiments, the authors provide compelling ...

Department of Chemistry, Saint Louis University, Saint Louis, Missouri 63103, United States Institute for Drug and Biotherapeutic Innovation, Saint Louis University, Saint Louis, Missouri 63103, ...

The aim of this study was to delineate PI3K/mTOR signalling in response to TGF-β 1 stimulation of primary human lung fibroblasts (HLFs), and to investigate the role of this pathway in TGF-β 1 mediated ...

This important study leverages the power of Drosophila genetics and sparsely-labeled neurons to propose a new model for neuronal injury signaling. The authors present convincing evidence ... Here we ...

Joseph foreshadows Jesus. Both are especially loved by their fathers; hated by their brethren; rejected as rulers over their brethren; conspired against; sold for silver; condemned though innocent; ...

Conclusions We describe here a novel mechanism of action of HCQ, that is, interference with the assembly of endosomal NOX2. Since endosomal NOX2 is involved in many inflammatory and prothrombotic ...

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