These features complicate the identification and description of ACPA-induced pathogenic mechanisms. In the current review ... different ACPA clones might have unique cellular targets and pathological ...

Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the discovery ... However, we have yet to fully elucidate the pathogenic mechanism of RA. Genetics-based drug ...

The classic signs of rheumatoid arthritis include pain, swelling, and stiffness of several joints. Persistent inflammation can lead to issues with mobility, fatigue, illness, and joint deformity over ...

Monoclonal antibodies are novel therapeutic agents used with great success in the treatment of rheumatoid arthritis (RA). Different parts of the immune system have been targeted by monoclonal ...

Rheumatoid arthritis (RA) is a form of arthritis and an autoimmune disease. An RA flare, also known as an exacerbation, occurs when a person experiences transient worsening of their rheumatoid ...

High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA). Fibroblasts have been in ...

Objectives Rheumatoid arthritis (RA), systemic ... immune cell expansion in the peripheral blood in pathogenesis of these ADs. Herein, we combined bulk RNA-seq and single-cell RNA-seq (scRNA-seq) of ...

autoantibodies against citrullinated IGF2BP1 are detected in patients with rheumatoid arthritis and positively correlate with disease severity.

Select the journal/section where you want your idea to be submitted: Immune evasion is a strategy used by pathogenic organisms to evade a host’s immune system ... a strong association between EBV ...

Immunity mechanisms of cytomegalovirus infection control have been studied recently and have contributed to the better understanding of the pathogenesis of this disease in patients with a solid ...

Different studies were able to show the presence of diverse synovial fibroblast (SF) subsets in the rheumatoid arthritis (RA) synovium using single-cell RNA sequencing ... different SF subtypes on ...