despite maintaining normal phagocytosis. Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ ...

leading to the activation of A1 astrocytes and M1 microglia and elevated neuroinflammatory cytokines. The disruption of this crosstalk between IL-3 and IL-3Rα induces lipid metabolic ...