Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages ...

Figure 3. The source of macrophage used to produce CAR-Ms and the tools employed for transducing CAR genes. Table 1. Preclinical and clinical trials of CAR-Ms. In 2018, Morrissey MA et al. created a ...

India CAR-Macrophage (CAR-M) recognizes specific tumor antigens through its chimeric antigen receptor (CAR), leading to enhanced phagocytosis of the tumor cells and concomitant presentation of tumor ...

Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented.

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...

Using lineage tracing, we find that tissue-resident red pulp macrophages (RPM), initially depleted by BCG exposure, are restored from both tissue-trained, self-renewing macrophages and from bone ...

Corticosteroids inhibit antigen ... tissue macrophages) play a major role in the induction and regulation of immune reactivity. Macrophages are intricately involved in the presentation of antigens ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

1Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P ...

Her condition was further complicated by the presence of autoimmune haemolytic anaemia and the development of macrophage activation syndrome while being evaluated for her blindness. Prompt treatment ...

However, whether CHIT1 plays a role in the response to acute ischemic stroke is unknown. Hypothesis: We hypothesized that sex-specific alterations in pro-inflammatory factors, including CHIT1, ...