While nicotine is known to enhance platelet aggregation, its effects on other platelet functions and underlying mechanisms remain unclear. Discussion: In conclusion, nicotine activates αIIbβ3 ...

Methods: In rats made cirrhotic by carbon tetrachloride (CCl 4) administration for eight weeks, we determined hepatic levels of PAF and its cognate receptor, and the effects of PAF and PAF antagonist ...

Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, ...

Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, ...

When thrombin was generated by the blood coagulation reaction, the platelets were activated by the thrombin through the thrombin receptor PAR-1 pathway. Such platelets could greatly contribute to the ...

Platelets circulate within the whole body and exert two principle functions: protection against bleeding and invading pathogens. Their multiple antimicrobial facets are beneficial, such as direct ...

In this regard, novel agents that target other platelet receptors such as the vWF or the collagen receptors are currently under investigation in preclinical studies. Promising data have been ...

The antibody drug conjugate was approved for patients with unresectable or metastatic HER2-low or -ultralow breast cancer ...

Megakaryocytes (MKs), known for their role in platelet production ... The review emphasizes the expression of immune receptors by MKs, such as toll-like receptors (TLRs), Fc gamma receptors ...