For example, one may imagine that irreversible inhibitors of the T. cruzi protease cruzaine would show severe side effects because they also target host cysteine proteases. However, these ...

Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

The inhibitor demonstrated high potency and selectivity for endogenous USP30 in neuroblastoma cells. Enzyme kinetics and hydrogen–deuterium eXchange mass spectrometry indicated that the inhibitor ...

Briefly, the indicated cells were lysed using RIPA buffer (Beyotime, China) supplemented with a protease and phosphatase inhibitor cocktail (CWBIO ... of the MAPK signaling pathway than did those in ...

Calcitonin gene-related peptide (CGRP) inhibitors are now considered a first-line treatment used to treat and ... The dosages vary, so talk with your healthcare provider about your dosing. For example ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

Quantitative and qualitative changes in matrix protease activity play an important ... and inhibited by binding to specific inhibitors known as tissue inhibitors of metalloproteinases (TIMPs).

There are several classes of antiretrovirals, which are defined by what step of viral replication they target: nucleoside reverse transcriptase inhibitors; non-nucleoside reverse transcriptase ...