Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

For example, one may imagine that irreversible inhibitors of the T. cruzi protease cruzaine would show severe side effects because they also target host cysteine proteases. However, these ...

Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany German Center for Infection Research (DZIF), Hannover-Braunschweig Site, ...

Examples in patients with non-small-cell lung cancer (NSCLC ... A separate retrospective analysis of a larger cohort of 1091 patients with advanced NSCLC who were progression-free after at least 2 ...

In a screen of more than 100,000 compound-target interactions, broad-acting CoV protease inhibitors were discovered and validated. Multiplexed drug screening can accelerate antiviral discovery, ...

The most common nephrotoxic effects associated with HAART include crystal-induced obstruction secondary to use of protease inhibitors (mainly indinavir and atazanavir), and proximal tubule damage ...

Department of Chemistry, University of Southern California, Los Angeles, California 90089-1062, United States Department of Chemistry, Stanford University, Stanford, California 94305-5012, United ...

These next-generation STAT6 inhibitors demonstrate excellent oral bioavailability, cell permeability, and metabolic stability, and do not target STAT6 for degradation. DeepCure expects to select a ...

For example, you may have worsened headache, nausea, or vomiting. In addition, consuming large amounts of alcohol can cause liver damage. In rare cases, Annovera may also cause liver problems as a ...

Therefore, in this study, we aimed to investigate whether the exposure time of serine protease XIV disrupts inhibition of NHE1 by SGLT2i in freshly isolated rabbit cardiac cells. We next tested ...

FIGURE 1. Different structural types of small-molecule MET kinase inhibitors. We focused on the design of new antiproliferative agents with potential interactions with MET active site as type II ...