Studies have shown that MM cells rely on the DDI2/NRF1 pathway for survival, as DDI2 activates Nrf1 when proteasome function is compromised. This activation leads to the upregulation of proteasome ...

The ubiquitin-proteasome system (UPS) is a non-lysosomal proteolytic pathway involved in numerous normal functions of the nervous system, modulation of neurotransmitter release, synaptic plasticity, ...

DUBs might function to regulate both the stability ... The physiological roles of DUBs are as pervasive as the ubiquitin–proteasome system itself. Here we use selected examples to illustrate ...

Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk 80-308, Poland ...

Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

2022). NF-κB primarily functions as a heterodimer complex composed of p65/RelA and p50, and its activation typically involves IκB degradation. However, emerging evidence suggests that the degradation ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

The body has specialised waste management factories (called proteasomes ... proteins can build up and impair the function of the heart, leading to heart disease. Heart disease caused by the ...

Akribion Therapeutics emerges from stealth with €8 million in seed funding to develop a novel cancer RNA-guided approach ...