Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas nonreceptor tyrosine kinases and serine/threonine protein kinases function throughout ...

Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signalling cascades.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...

Its activation then triggers a broad spectrum of downstream cascades to promote numerous effects ... ADCC, antibody-dependent cellular cytotoxicity; Akt, protein kinase B; c-Cbl, Casitas B-lineage ...

Kinases have a pivotal role in phosphorylation and kinase dysregulation has been implicated in the occurrence and progression of various diseases. By mid-2024 the Food and Drug Administration had ...

People with diabetes should eat as much protein as people who don't have diabetes. In a healthy diet, roughly 10% to 35% of your daily calories should come from protein. Protein itself does not have ...

An enzyme that helps clear damaged mitochondria can act as a molecular switch and potentially prevent neurons from dying.

"Yet, as imperfect as it may be, the kinase evolutionary tree is widely used to understand how it interacts with other drugs. Improving this tree, or improving trees of other important protein ...

Scroll through TikTok or Instagram and you’ll be inundated with protein-centric recipes. Maximizing protein is a huge trend right now on social media—and not just in the usual suspects ...

lenta. Smoke-exposed mice display impaired colonic epithelium and enhanced oncogenic MAPK/ERK (mitogen-activated protein kinase/extracellular signal‑regulated protein kinase 1/2) and proinflammatory ...

After 4-h treatment with these drugs, cells were then subjected to further processing for immunoblotting or kinase assay. The protein extracts were prepared through the following procedure: cells were ...