Mitogen-Activated Protein Kinase (MAPK) signaling pathways play a crucial role in various cellular processes, including growth, differentiation, and response to stress. These pathways are ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

Researchers have discovered how a particular protein affects the growth and spread of colon cancer in humans. The study not ...

These authors contributed equally to this work.

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

The overarching goal of our research is to identify and characterise protein kinase signalling pathways that are disrupted in human neurodevelopmental disorders. Protein kinases function as reversible ...

PRESS RELEASEAB SCIENCE PROVIDES AN UPDATE ON ITS MASITINIB PLATFORMParis, January 29, 2025, 7pm CETAB Science SA (Euronext - FR0010557264 - AB) ...

"Rasopathies are a group of rare genetic disorders that are caused by mutations in genes that regulate the Ras/mitogen-activated protein kinase (MAPK) signaling pathway." "Given the rarity of this ...

These factors impact several signaling pathways in chondrocytes, collectively regulating joint homeostasis. Some of these factors alleviate OA progression by playing positive roles in its pathogenesis ...

A study study has uncovered the complex role of abscisic acid (ABA) in regulating chlorophyll accumulation in apple plants.

Plant pests such as bacteria and fungi lead to significant yield losses in agriculture. In order to develop new strategies ...