In this diagram of G-protein-coupled receptor activation, the alpha, beta, and gamma subunits are shown with distinct relationships to the plasma membrane. After exchange of GDP with GTP on the ...

The fatty membrane surrounding every living cell is a vibrant environment where countless biological processes take place.

A plasma membrane is permeable to specific molecules that a cell needs. Transport proteins in the cell membrane allow for selective passage of specific molecules from the external environment.

We are also actively investigating the regulation of Syk tyrosine kinase binding to membrane immune receptors and other signaling proteins. Syk recognizes doubly phosphorylated regions of the receptor ...

An enzyme that helps clear damaged mitochondria can act as a molecular switch and potentially prevent neurons from dying.

In secretory cells such as gonadotropes, the cytoplasmic face of the plasma membrane is associated with a dense meshwork of actin filaments (termed cortical actin) and actin binding proteins that ...