Protein phosphorylation is a covalent post-translational ... we have catalogued 132 phosphotyrosine-based motifs consisting of 50 tyrosine kinase substrate motifs, 19 tyrosine phosphatase ...

a good activator of PKB/Akt but not of mitogen-activated protein (MAP) kinase, failed to induce endogenous BAD phosphorylation, although it did promote survival. In addition, both IL-3 and ...

Researchers discovered that ALPK2, a heart-specific enzyme, may protect against HFpEF by activating TPM1 in heart muscle ...

Tatsuya Yoshida, Mikito Takefuji, and Toyoaki Murohara in the Department of Cardiology, Nagoya University Graduate School of Medicine, identified an enzyme, alpha-kinase 2 (ALPK2) that is specifically ...

What is ALPK2, and how can it help treat heart failure? Researchers have found that this heart-specific enzyme may prevent ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct ...

Recent research has observed that chemical modifications called phosphorylation of proteins ... have discovered that protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 ...

Plant pests such as bacteria and fungi lead to significant yield losses in agriculture. In order to develop new strategies ...

Acute myeloid leukaemia (AML) is mainly characterized by an increase in the number of myeloid cells in the bone marrow and a decrease in mature cells, accounting for 28% of leukaemia cases, with a ...

They found that HT promoted SMT glycogen synthesis, increased the phosphorylation level of protein kinase B (AKT), and lowered blood glucose levels in SMT, indicating that HT improved insulin ...