Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Lactate can also be converted to lactoyl-CoA, which is involved in the lactylation of histone and non-histone proteins. HK-1, hemokinin-1; G6PD, glucose 6-phosphate dehydrogenase; PKM, glycolytic ...

Expression systems are genetic constructs (a gene encoded by DNA) that are designed to produce a protein, or an RNA (ribonucleic acid), either inside or outside a cell. Expression systems are used ...

Malignant cells support tumor proliferation and progression by adopting to metabolic changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of glucose to lactate, even ...

Researchers have developed a new method for growing T cells in the lab, allowing them to survive longer and fight cancer more effectively. This advancement, detailed in Cell Metabolism, could ...

日前，Saol Therapeutics宣布，美国FDA已受理其在研疗法SL1009的新药申请（NDA），用于治疗丙酮酸脱氢酶复合物缺乏症（PDCD）。FDA已授予该申请优先审评资格，并设定PDUFA日期为2025年5月27日。

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...