the antisense strand has to be incorporated into the RNA-induced silencing complex (RISC). It turns out that the relatively low thermodynamic stability in the 5′ end of the antisense siRNA ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

Figure 3: Roles of the Argonaute complex in miRNA and RNAi pathways. Seminal studies in C. elegans and plants have uncovered the important role carried out by Argonaute proteins in RNA silencing ...

Our group has structurally characterized and mechanistically defined events associated with processing of long double-stranded RNAs into siRNAs by the endonuclease activity of Dicer and ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

Benitec has a market cap of $250mn, $67.8mn in cash, and a cash runway of over 10 quarters, but faces risks due to its small ...