To create one of the most advanced immunotherapies in cancer, CAR-T cell therapies, scientists engineer immune T cells to carry a synthetic protein on their surfaces. This protein, called the ...

The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...

In doing so, they discovered a novel immune response state, which they called PRIMER, that emerged in cells at specific immune hotspots. The PRIMER cells expressed a new transcription factor—a ...

The immune cells are postulated to exert a pivotal role in the development of fibrotic skin disease. Single-cell RNA sequencing has been used to explore the composition and functionality of immune ...

Their study in mice found that during periods of low energy— such as intermittent fasting—ILC2 immune cells step in to regulate blood sugar levels, acting as a “postman” in a previously ...

The goal of the transplant is to replace the patient’s hematopoietic stem cells – cells that rejuvenate supplies of blood and immune cells – with donor stem cells that are not cancerous. In addition, ...

Scientists have created a new atlas of plant cells during immune response, in turn discovering a new rare cell state, called Primary IMmunE Responder (PRIMER), that acts as an immune response hub ...

31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...

The cytokine IL-33 and ILC2 immune cells are critical to TLS formation Previous research published in Nature by Dr. Balachandran's team found that an unusual type of immune cell called group 2 ...

In addition, it can deplete regulatory T cells, thereby overriding their antitumour immune responses. Anthracyclines can induce an immunogenic variant of apoptosis in tumour cells, thereby ...

This "targeting system" is an artificial protein called a chimeric antigen receptor (CAR) that helps immune cells recognize and attack cancer cells. While current CAR T-cell therapies require ...