Among the several effects of seizures on neurons is an increase in intracellular Ca 2+ and activation of RhoA. Rapamycin is mTORC1 inhibitor, but long-term exposure to rapamycin (>18 hours) could also ...

Sirolimus (rapamycin) is a drug used to upregulate autophagy in cell culture in the laboratory, and in clinical practice to prevent rejection following organ transplantation due to independent ...

Research on the development, physiology and pathophysiology of reproductive disorders is important, as evidence suggests that many adult-onset diseases can be traced back to disruptions during early ...

Its lead product candidate is QTORIN 3.9% rapamycin anhydrous gel (QTORIN rapamycin) that is in Phase 3 clinical trial for the treatment of microcystic lymphatic malformations, as well as in Phase ...

Newer agents may provide better specificity. Rapamycin inhibits the growth factor mTOR (mammalian target of rapamycin), which is activated by both physiological and pathological hypertrophy.

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Like people, words have birthdays. My definition of the birthday of a word is the year in which it first appeared in a ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including ...

Lissencephaly belongs to a group of disorders we call malformations of cortical development, meaning the normal development and structure of ... (mammalian target of rapamycin) pathway in both ...

"Lissencephaly belongs to a group of disorders we call malformations of cortical development, meaning the normal development and structure ... (mammalian target of rapamycin) pathway in both ...

In the MUT group, osteoblasts were transfected with plasmid carrying Beclin-1 protein-encoding sequence. To induce autophagy of osteoblasts, Rapamycin (Rapa) (Selleck Chemicals) was used as the ...