p53 dysfunction and mTOR pathway hyperactivation are hallmarks of human cancer ... serves as a scaffold for mTORC1 via interacting with Raptor (Sancak et al., 2008; Sancak et al., 2010). To maintain ...

Intriguingly, several overlaps have been shown between the two disorders, e.g., inflammatory activation, oxidative stress, glucose and insulin pathways, wingless-INT/mammalian target of rapamycin (Wnt ...

Murine hematopoietic cells were transduced with ecotropic supernatants (Figure 1b), using conditions that led to efficient gene marking with low provirus copies (<3) per cell. 23 Polyclonal ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

Samson Folk is joined by Joe Wolfond & Blake Murphy to discuss the Raptors and the NBA post-deadline.