Announcing a new article publication for BIO Integration journal. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in China in December 2019, rapidly spread worldwide, ...

A newly developed vaccine against a group of viruses including SARS-CoV-2 is producing promising results in mice, part of the ...

Ubiquitin-binding domains (UBDs) are modular elements that ... including protein stability, receptor trafficking, DNA damage responses and inflammatory pathways. UBD preferences for distinct ...

Traditional vaccines typically focus on the most accessible parts of viruses, which are often the rapidly mutating ...

They all share a mutation called N501Y that affects the receptor binding domain (RBD) of the spike protein, which the virus uses to clasp onto human cells’ receptors and enter them. That mutation ...

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“We computationally predict what mutations allow better binding to host receptors and better evasion of antibodies,” said Boston College Assistant Professor of Biology Babak Momeni, a lead researcher ...

Intracellular plant protein complexes called nucleotide-binding domain, leucine-rich repeat receptors (NLRs) bind bacterial effectors and set off secondary immune cascades that boost the ...

All the ERBB receptors except ERBB2 have known ligands, and all except ERBB3 have relatively active kinase domains. Although ERBB2 is minimally active in ligand binding, it is the preferred ...

Cys-loop receptors are ligand-gated ion channels ... interrupted the bottom domain's ability to feel the binding activity of the top domain. Like the sandy contents inside a child's magnetic ...