Groundbreaking research on the differentiation of embryonic stem cells (ESCs ... aberrant transcript were detected in retinal organoids, co-incident with photoreceptor differentiation and the ...

In view of the oxygen-rich environment in the eye, it is particularly noteworthy that phospholipids containing docosahexaenoic acid (DHA), which are exquisitely sensitive to oxidative damage (1), are ...

Using the stem cells, the researchers made "retinal sheets" that are enriched in immature versions of the cone photoreceptor cells, which could become mature cone cells when cultured in the lab.

Based on in situ hybridization and hypothyroid studies, thyroid hormone appears to target photoreceptor development. The hormone may be acting in at least two ways. It could instruct neuronal ...

It also disrupts blood vessels that are situated behind the retina. This disrupts normal cell metabolism, leading to the death of photoreceptor cells and, eventually, geographic atrophy ...

Disruption of photoreceptor cilia has been implicated in a variety of retinal diseases, collectively called retinociliopathies, such as Leber congenital amaurosis and retinopathy of prematurity.