Background Rett syndrome is a complex genetic disorder with age-specific manifestations and over ... For consistency, we focused our analysis on the 50 patients with MECP2 pathogenic variants or a ...

The complexities of gene therapy coupled with the specific requirement to correct only cells with abnormalities in MECP2 render gene-based therapies for RS problematic at this time. One promising ...

Rett syndrome, MECP2-related, crab-eating macaque (MONDO:1012890) XY sex reversal, SRY-related, horse (MONDO:1012653) neuroaxonal dystrophy, TECPR2-related, dog (MONDO:1012763) progressive retinal ...

The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD). Individuals with ASD typically have impairments in hippocampus-dependent learning, memory, language ability, ...

Metabolic syndrome is a constellation of conditions that together increase the risk of type 2 diabetes, stroke, and cardiovascular problems, including heart attack. The features of metabolic syndrome ...

Prenatal alcohol exposure is associated to different physical, behavioral, cognitive, and neurological impairments collectively known as fetal alcohol spectrum disorder. The underlying mechanisms of ...

Single-molecule biophysics is the study of the dynamics and interactions of individual biomolecules to understand how they carry out their functions in living cells. For example, monitoring the ...