These toxins are known for their ability to modify Rho GTPases, which are proteins that regulate various cellular processes, including the organization of the cytoskeleton and cell signaling.

They include chemokine receptors, the TCR and integrins such as LFA-1, each being interconnected with the actin cytoskeleton with specific sets of signaling molecules. Ligand-mediated triggering of ...

The exocyst complex is regulated by Rab and Rho small GTPases, resulting in docking of exocytic vesicles to the plasma membrane (PM) and finally their fusion mediated by specific SNARE complexes. In ...

Small GTPases of the Rho family are potent modulators of the actin and microtubule cytoskeleton. Recent data indicate that the Ras-like RAP1 protein and various Rho proteins crosstalk to polarity ...

The LPA-induced change in endothelial permeability was accompanied by changes in the F-actin cytoskeleton. In control ECs ... basal permeability and completely prevented the LPA-enhanced HRP passage ...

The study also revealed that defective S1P/S1PR1 signaling in susceptible mice disrupted the actin cytoskeleton, which is essential for the stability and adaptability of the synaptic connections in ...

Proteomics Approaches to Analysis of the Cytoskeleton in Immune Cells Cytoskeletal proteins are often identified in many proteomic studies either as contaminants, owing to their very high ...

This fundamental work extends our understanding of the role of TGFβ2 as a modulator of mechanosensing in the eye and identifies the TRPV4 ion channel as a common regulator of Trabecular Meshwork (TM) ...

Valo Health’s Rho kinase (ROCK) 1 and 2 inhibitor has failed to reduce the severity of diabetic retinopathy in a phase 2 trial, leading the Flagship-founded biotech to drop the candidate.

School of Cardiovascular and Metabolic Medicine & Sciences, King’s College London, London WC2R 2LS, U.K. Faculty of Medicine, Department of Biomedical Sciences, Masaryk University, 62500 Brno, Czech ...

Department of Physiology and Pathophysiology (Y.T., Y.J., L.F., H.L., Y.L., J. Zhu., W.P., J. Zhou), School of Basic Medical Sciences, Peking University, Beijing ...