multistep conduit for signal transduction in the cell cycle. You have full access to this article via your institution. The apparently simple step of inhibition of a protein-protein interaction by ...

and OSI Pharmaceuticals is focusing its preclinical and early clinical efforts on G-protein coupled receptors. In addition, several observations in signal transduction research are showing clear ...

Davis, University of Massachusetts Medical School, Howard Hughes Medical Institute. The signal transduction pathways of mitogen-activated protein (MAP) kinases have been actively studied for some time ...

Attisano, J.L. Wrana, "MADR1, a MAD-related protein that functions in BMP2 signaling pathways," Cell ... If there is one thing that is known about the mechanisms that govern signal transduction, it's ...

Increased understanding of signal transduction mechanisms and gene regulation involved in immune responses has created opportunities for the discovery of novel therapeutic compounds useful in treating ...

The specific targeting of signal transduction by low-molecular-weight inhibitors or monoclonal antibodies represents a very promising personalized treatment strategy in pediatric oncology. In this ...

View the photo gallery. Cellular and molecular biology, protein tyrosine phosphorylation, pseudophosphatase roles in signal transduction, protein:protein interactions Year of arrival: 2010, Professor ...

G protein-coupled receptors (GPCRs) play an essential role in the regulation of many physiological processes, and they represent a major target for already validated as well as newly emerging drugs in ...

By using various linker lengthening mutations in this interfacial region of the protein, Godellas and ... questions about what limits signal transduction. In the meantime, the Grosman lab will ...

Protein S-sulfenylation is one kind of crucial post-translational modifications (PTMs) in which the hydroxyl group covalently binds to the thiol of cysteine. Some recent studies have shown that this ...

Neurons or nerve cells are the fundamental components of the central nervous system and are critically involved in signal transduction ... or electrical (protein channels and ions).