In recent years, scientific advancements have transformed our understanding of diseases, particularly at the cellular level.

Our results demonstrated an example where long-read sequencing was capable of accurately resolving complex breakpoints for inversions. Haplotype identification of chromosomes is of great importance to ...

Recent syngnathid genome assemblies revealed suggestive gene content differences and provided the opportunity for detailed genetic analyses. We created a single-cell RNA sequencing atlas of Gulf ...

After isolation of cells from the four areas of tissues, a 10 × Genomics Single Cell v2 kit was used for sequencing library preparation per the manufacturer’s ... Paraffin-embedded tissues can be ...

A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.

Scientists gain valuable insights into cellular diversity and functions, disease mechanisms, developmental processes, and drug responses by examining the transcriptome of tissues using single-cell RNA ...

The research shows that as long as essential genes remain intact, our genomes can tolerate significant structural changes, ...

One PWS case with a previously unresolved diagnosis subtyped as maternal isodisomy. This work highlights the application of long-read sequencing and other imprinted regions outside of the PWS/AS ...

Design We performed single-cell RNA sequencing and spatial transcriptomic analysis in primary colorectal cancer (CRC) and metastases in the liver (lCRC) or ovary (oCRC). We also conducted ...

A generative AI-based technique can predict thousands of 3D genomic structures in just minutes, enabling researchers to more ...