The ECM (extracellular matrix) provides the microenvironmental niche sensed by resident vascular smooth muscle cells (VSMCs). Aging and disease are associated with dramatic changes in ECM composition ...

This multiscale modeling approach allows for a more comprehensive understanding of how microscopic changes can impact macroscopic muscle function. Furthermore, computational models have been ...

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs ...

"Predictive generalizable computational ... that govern cell behavior." In recent years, the accumulation of massive amounts of data from cells and more powerful AI models are starting to ...

Computational models are mathematical models that are simulated using computation to study complex systems. In biology, one example is the use of a computational model to study an outbreak of an ...

In the same way that ChatGPT understands human language, a new AI model developed by computational biologists captures the language of cells to accurately predict their activities. In the same way ...

Smooth muscle lacks the striated structure of skeletal muscle and instead consists of sheets or layers of smooth muscle cells. When stimulated by the autonomic nervous system to contract from the ...

Thus, a damaged heart after a heart attack cannot repair itself by growing new muscle cells in the scar area left by the heart attack. Many previous pig model preclinical trials to inject new heart ...

Using Parkinson’s disease as a case study, we review here how computational ... While the above models seek the consequences of dopamine depletion on the dynamics of the striatum and wider basal ...

Researchers have developed a new method to grow T cells that have greater longevity and can more efficiently destroy cancer cells in mouse models of melanoma compared to those grown in traditional ...

Computer science has transformed biology and medicine. The next generation of life scientists must be well-versed not only in laboratory techniques for data generation but also in the computational ...

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