Stem cells are cells that have the capacity to self ... Non-invasive lineage tracing in humans relies on rare somatic mutations, which have limited throughput and temporal resolution.

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells ...

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

New research shows persistent DNA lesions in stem cells contribute to mutations, with links to blood cancers and external ...

Scientists at the Wellcome Sanger Institute uncovered DNA damage that can persist for years, evading repair mechanisms and increasing mutation risks. This phenomenon provides new insights into cancer ...

The emergence of induced pluripotent stem cell (iPSC) technology has had a great impact on the field of medicine ever since the ground-breaking discovery in 2006 that overexpression of four specific ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

Your body is a collection of cells carrying thousands of genetic mistakes accrued over a lifetime—many harmless, some bad and ...

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity ...