Objective—Somatostatin (SST ... and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in regulating α- and β-cell function. However, the specific intraislet ...

A new study has uncovered a critical role for the enzyme Glucose-6-phosphatase 2 (G6PC2) in regulating blood sugar levels.

On day 1, GLP-1 was infused to stimulate endogenous insulin release and suppress endogenous glucagon. On days 2–5, pancreatic endocrine clamps were performed using somatostatin infusions of ...

New findings raise the possibility of promising therapeutic strategies for the management of hypoglycemia in type 1 diabetes ...

Acromegaly is due to hypersecretion of growth hormone and insulin-like growth factor I ... Medical treatment of the disease is usually with somatostatin analogs. An open, prospective, single ...

beta cells secrete insulin, and alpha cells secrete glucagon. Scientists have identified three additional cell types in islets, including cells that secrete the hormones somatostatin, ghrelin ...