Emerging antidiabetic drugs sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1RAs), and dipeptidyl peptidase-4 inhibitors (DPP-4i) have demonstrated ...

Advances in synthetic biology and the clinical application of bacteriotherapy enable the use of genetically engineered bacteria (GEB) to combat various diseases. GEB act as a small ‘machine factory’ ...

This paper highlights the use of SMART in several biological test cases including cellular mechanotransduction, calcium signaling in neurons and cardiomyocytes, and adenosine triphosphate synthesis.

Small-molecule activators and inhibitors support a model in which S1P signaling must be inhibited to generate Müller glial progenitor cells-a key step in retinal regeneration. The presented results ...

This article explores methods to enhance efficiency in the drug discovery and development pipeline, focusing on optimizing ...