We used Toll-like receptor-specific reporter cells and reporter cells harbouring knockouts of cGAS, STING and IFNAR2 to evaluate signalling pathway-dependent ISG induction. Results IFN-I bioactivity ...

Members of the TLR family have the propensity to detect a range of microbial products such as ... derived nucleic acids has witnessed fruitful progress and disclosed important signaling cascades such ...

This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss ...

Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China ...

View Full Profile. Learn about our Editorial Policies. When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team wanted to identify ...

It also describes how TLR signaling could affect the stem cell regulatory pathways. 3 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center ...

Indaptus Therapeutics, Inc. (Nasdaq: INDP) (“Indaptus” or the “Company”), a clinical-stage biotechnology company pioneering innovative cancer and viral infection treatments, today announced the ...

There's Actually an Incredibly Easy Way for Elon Musk to Trim $2 Trillion of Government Spending: Cut Funding for Nuclear Weapons ...

It is not yet understood whether ISCs also express other TLR components and whether the TLR pathway is functionally active in ISCs. Intestinal stem cell-specific TLR4 expression affects the ...

2490 Ewald Ave. S.E.