Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent ...

Ovarian tumors are infiltrated by both effector (CD4+CD25-) T cells and by an excess of TREG cells (CD4+CD25+). These TREG cells impede the function of the effectors in combating the tumor.

Background and aims: Coeliac disease is a common small intestinal inflammatory disorder that results from a breach of intestinal tolerance to dietary gluten proteins, driven by gluten-reactive ...

The human immune system is a complex network of cells and signals that guards against disease, yet in the case of cancer, it often struggles to mount an effective response. Recent research, published ...

IL-1 signaling in DCs promotes their ability to induce T cell activation, but also direct action of IL-1 on both CD4 + and CD8 + T cells, either alone or in synergy with ... signaling via the IL-1R ...

Measuring CD4 T-cells is important in helping healthcare providers determine the stage and likely outcome of HIV infection. While they are no longer used to determine when HIV therapy should be ...

1Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. 7Yonsei New Il Han Institute for Integrative Lung Cancer Research, Yonsei University College ...

Co-expression of the inhibitory receptors PD-1 and CD73 regulates tolerance by restricting the expansion of auto-reactive CD4 + T cells independently of thymic selection. Fungal spores can promote ...

CD4-positive T cells are a subtype of lymphocyte. They are MHC class II-restricted and are important mediators of adaptive immunity. These cells are involved in both the induction and the ...

The following is a summary of “FC03 T17 polarization of skin-homing (CLA-positive) T cells is maintained by ...

Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T ...

Novel programs will combine validated cell-targeted LNP (ctLNP) delivery with siRNA to selectively modulate T cells in vivoPrograms to focus on silencing hard-to-drug targets of high therapeutic value ...