Tinidazole is a structural analog of metronidazole and has been available in Europe for more than 2 decades. After activation, its toxic intermediates covalently bind to DNA, resulting in DNA ...
One exception to this rule is for metronidazole and tinidazole, prodrugs that are activated in the bacterial cell by bacterial enzymes. There are several H. pylori nitroreductase enzymes that can ...
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