Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Macrophage polarization states are indeed crucial for their functions, with the M1 phenotype closely associated with anti-cancer properties. Notably, M1 macrophages can exert cytotoxic effects, which ...

The biotech’s approach to fighting cancer is based around “repolarising” tumour-associated macrophages (TAMs) using small molecule drugs so that they no longer suppress the immune system ...

An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that ...

The Arkansas Integrative Metabolic Research Center will host Jeffrey Rathmell, a professor of pathology, microbiology and immunology from Vanderbilt University on Wednesday, Jan. 22.

Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immunosurveillance mechanisms. Dura-derived immunosuppressive macrophages are ...

Studies exploring skeletal muscle macrophage activity are needed to explore the inflammatory pathway associated with obesity and comorbidities ... apoptosis-linked gene 2-interacting protein X (ALIX), ...

Discover how immune iFRET biomarkers offer new insights into predicting response to neoadjuvant melanoma therapy, driving ...

Cancer-associated fibroblasts (CAFs), distinguished ... the interactions between CAFs and innate immune cells (such as macrophages, neutrophils, mast cells, etc.) as well as adaptive immune ...

Researchers identify distinct molecular and immune profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma.