【导读】肿瘤相关巨噬细胞（TAMs）通常被认为是肿瘤发生和肿瘤发展的帮凶。然而，肿瘤细胞促使 TAMs 协助逃避免疫监视的确切机制仍有待进一步研究。1月24日，浙江大学医学院附属第一医院郑树森院士研究团队在期刊《Advanced ...

In this Research Topic, we aim to explore either of the following themes: 1. Key Immune Components in the Tumor Microenvironment 1.1. Tumor-Associated Macrophages (TAMs): TAMs (M1) are often polarized ...

The acidic environment promotes tumor stem cell phenotype and immune escape. Tumour-associated macrophages (TAM) are important components of the immune microenvironment that promote tumour progression ...

activating nearby antigen presenting cells (APCs), notably dendritic cells (DCs), and repolarizing tumor-associated macrophages (TAMs) toward an M1 phenotype. In addition to direct phagocytosis of ...

and tumor-associated macrophages as well as uncovering crucial adaptive T cell regulation pathways in cancer. Using murine genetic cancer models and patient tumor specimens, we were the first to ...

Results Tumour-associated macrophages that employ efferocytosis to eradicate apoptotic cells ... but this has little impact on the growth of pancreatic cancer. Macrophage efferocytosis induces a wound ...

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk ...

Macrophage polarization states are indeed crucial for their functions, with the M1 phenotype closely associated with anti-cancer properties. Notably, M1 macrophages can exert cytotoxic effects, which ...

In the new study, which focused on breast cancer, the authors report that tumor-associated macrophages (TAMs), a type of immune cell found abundantly in the tumor microenvironment, respond to the ...

The study introduces an innovative tracer targeting CD163, a molecular receptor on tumor-associated macrophages—immune cells that support tumor growth and protection. The tracer is based on ...