【导读】 利用核糖核酸酶靶向嵌合体（RiboTACs）降解RNA，是一种很有前景的癌症治疗方法。然而，潜在的脱靶降解是一个严重的问题。在这项研究中，团队设计了一种能触发肿瘤微环境激活的RiboTAC。

通过线粒体转移，癌细胞不仅实现了对T细胞功能的精确抑制，还为其免疫逃逸增加了一道屏障。该研究进一步指出，这种机制与免疫治疗效果不佳密切相关，尤其是在携带大量mtDNA突变的患者中，免疫检查点抑制剂的疗效显著降低。

Lung cancer treatment and outcomes are profoundly influenced by the tumor microenvironment (TME), particularly in resectable ...

鳞状细胞癌与基底细胞癌均来自于角质形成细胞的癌变，黑色素瘤来源于黑色素细胞癌变，因此在第一部分内容分析BCC，SCC,黑色素瘤细胞生态图谱后，研究团队将目光聚焦于角质形成细胞以及黑色素细胞。健康角质形成细胞和肿瘤角质形成细胞的二级聚类导致明显分离的健 ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

Nutrient access and metabolism regulate lymphocyte function, crucial in demanding environments like tumors. Dr. Delgoffe ...

D tumoroid models transform cancer research, accurately reflecting tumor biology and enabling effective drug testing and ...

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a ...

Scientists have progressed from merely provoking an anti-cancer immune response to designing it ...

Researchers at the University of Pennsylvania have introduced lab-engineered small extracellular vesicles to target tumors in ...