2.2. Helper T Cells (Th): Th1 cells support anti-tumor immunity by activating CTLs and macrophages, while Th2 cells can contribute to immunosuppression and tumor progression. 2.3. Natural Killer (NK) ...

In our breast and ovarian cancer study, all patients had low Treg (CD4 +, CD25 + and CD127) profiles prior to starting chemotherapy; however, by day +14 as the percentage of circulating NK cells ...

Cancer Institute of New Jersey, New Brunswick, NJ, United States This review article explores the rapidly evolving field of bi-, tri-, and multi-specific NK cell engagers (NKCEs), highlighting their ...

NK cells have cytotoxic functions that kill cancer cells, but when TM4SF5 is overexpressed, this function is diminished. The research team reported that TM4SF5 overexpression and the functional ...

Creating cancer therapies based around natural killer cells could offer similar levels of efficacy to CAR-T therapies, but at around one hundredth of the cost. Researchers at MD Anderson Cancer ...

The researchers compared mitochondria from each person’s cancer cells with those from the same individual’s tumour-infiltrating lymphocytes (TILs) — immune cells that recognize and invade ...

Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...

Cancer cells divide more rapidly than normal cells, so most cancer treatments focus on killing these fast-dividing cells. However, this often leads to side effects since normal cells can also be ...

so need to be activated before they attack cancer cells that present antigens. NK cells are part of the innate immune system, a first line of defense that doesn't need to be primed into action.

This valuable study provides solid in vivo data that transfer of IL-15/IL-12-conditioned syngeneic NK cells after primary tumor resection promotes long-term survival of mice with low metastatic burden ...

Of note, an investigator-initiated clinical trial demonstrated that similar NK cell infusions in cancer patients after resections were safe and showed signs of efficacy, which is of promising clinical ...