During islet development, beta-cell death, rather than proliferation alone, regulates beta-cell mass and shapes the immune ...

Background and objective Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic ...

DeadEnd™ Fluorometric TUNEL System (G3250) were purchased from Promega (America ... After 24 h, 10 μ of CCK-8 solution was added to each well. The cytotoxicity assay was measured with the Cell ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

Apoptotic cells in the lung of mice were detected using the DeadEnd™ Fluorometric TUNEL System. Results: Our results showed that experimental SSc ... The level of anti-AT1R autoantibodies in the mouse ...

Doxorubicin‐induced cardiotoxicity is still an important medical problem associated with a high mortality rate in cancer survivors. p53 plays a key role in doxorubicin‐induced cardiotoxicity.

Pre-miR-148a was delivered specifically to hepatocytes in vivo using lentivirus. Immunoblottings, luciferase reporter assays, chromatin immunoprecipitation and immunofluorescence assays were carried ...

Supernatant were collected and measured for the level of IL-1β (DY401) and IL-6 (DY406) according to manufacturer’s instructions by sandwich enzyme-linked immunosorbent assay (ELISA) (R&D System ...

Objectives The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear ...