The cross action between ubiquitination and proteins in these signal cascades enhances the antiviral signal. On the contrary, more and more viruses have also been found to use the ubiquitination ...

Further studies revealed that PD disturbed the overall ubiquitination level in GC cell lines and enhanced the ubiquitination-dependent degradation of c-Myc. Interestingly, the inhibition of cell ...

This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' ...

【导读】目前，靶向晚期透明细胞肾细胞癌（ccRCC）的治疗选择尚不充分。早期研究已表明，甲基转移酶样蛋白 14（METTL14）可通过 N6-甲基腺苷（m6A）的修饰来抑制 ccRCC ...

Ubiquitin is an intracellular signalling molecule that is conjugated to various proteins. Ubiquitin conjugation to itself yields Lys- or Met-conjugated chains, thus expanding its repertoire of ...

USP14 regulates PERIOD (PER) protein stability post-translationally in Drosophila via interaction with SLIMB, a protein involved in PER degradation, and Lys1117 and Lys1118 are key ubiquitination ...

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Hartmut received his PhD from the University of Vienna for his work on ubiquitination and the cell cycle carried out in the group of Jan-Michael Peters. In his postdoctoral work in the laboratory of ...

【导读】结直肠癌（CRC）是全球最常见的癌症之一，肝转移是其致死的主要原因。环状 ...

The Department of Biochemistry and Molecular Pharmacology at NYU Langone Health has a rich and distinguished history and maintains active research programs in epigenetics, genome integrity, protein ...

The USP9X inhibitors WP1130 and EOAI3402143 were used to treat the DSS-induced colitis. Ubiquitination label-free quantitative proteomic analysis was performed to identify protein peptides that may ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...