Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

Thus M cells may represent a transient and reversible phenotype. M cells are important in regulating access of microorganisms and antigens to areas of the intestinal immune system equipped to generate ...

The functionality of YAP allows cells to progress into mitosis despite DNA damage remaining unrepaired, achieved by inducing the expression of IGF2 and activating Akt, consequently leading to the ...

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...

Based on RNAi combinations and double mutant clonal analyses, they propose that Numb has a function in inhibiting Notch pathway to maintain intestinal stem cells, and is a backup mechanism with BMP ...

These studies have also revealed how proper development and function of the intestinal immune system is dependent on its specific microbiota, which appears to have evolutionarily co-evolved. Here we ...

Differentiated co-cultures (21 days, dynamic conditions) were exposed apically to 0.5 mL of diluted digesta for 3 h at 37°C, approximating physiological intestinal transit time (Hardy et al., 1989).

Background: We showed that intestinal epithelial stem cells (IESCs) obtained from healthy young donor rats and transplanted to aging animals after stroke reduced infarct volume and sensorimotor ...

Crohn’s disease-related inflammation can sometimes lead to intestinal blockage. Untreated, an intestinal blockage may lead to serious complications. Crohn’s disease is a chronic condition that ...

Intestinal villi (singular: villus)are tiny, finger-like projections that line the interior (lumen) of the small intestine. The primary function of villi is to absorb nutrients from food and transfer ...